Skip to main content
. 2013 Jan 23;14:12. doi: 10.1186/1471-2202-14-12

Table 1.

Contractile effects of ET-1, U46619, Ang II and 5-CT in human cerebral arteries

  N K+ mean ± s.e.m Emax (%) ± s.e.m pEC50 ± s.e.m
ET-1
  
  
  
  
Control
 6
 6.76 ± 1.32
 107 ± 12a
 7.20 ± 0.89
Organ Culture
 6
 4.37 ± 1.21
 143 ± 22 a,b
 8.74 ± 0.25
Organ Culture + U0126
 7
 3.53 ± 0,90
 57 ± 8 b
 8.49 ± 0,10
U46619
  
  
  
  
Control
 7
 8.26 ± 1.98
 102 ± 15a
 7.35 ± 0.74
Organ Culture
 7
 5.10 ± 1.60
 141 ± 11a,b
 7.18 ± 0.18
Organ Culture + U0126
 4
 3.65 ± 1.89
 76 ± 40b
 6.64 ± 0.10
Ang II
  
  
  
  
Control
 6
 1.67 ± 0.54
 12 ± 2a
  
Organ Culture
 5
 4.44 ± 1.92
 43 ± 12a,b
 9.15 ± 0.82
Organ Culture + U0126
 4
 4.46 ± 2.41
 1 ± 1b
 9.05 ± 1.13
5-CT
  
  
  
  
Control
 6
 6.76 ± 1.36
 50 ± 8
 7.45 ± 0.66
Organ Culture
 4
 3.90 ± 1.59
 17 ± 5b
 7.35 ± 1.21
Organ Culture + U0126 7 3.53 ± 0.90 2 ± 1b 7.38 ± 0.73

Responses were characterized by Emax values, expressed as percent of 63 mM K+ -induced contraction, and pEC50 values (negative logarithm of the molar concentration that produces half maximum contraction). Values are represented as mean ± s.e.m and n represents number of patients. a = significant difference between organ culture and control groups, b = significant difference between organ culture and organ culture treated with U0126.