Table 2.
Receptor protein levels in human cerebral arteries
| Control | Organ.Culture | Organ Culture + treatment with U0126 | |
|---|---|---|---|
| ETB (%) ± s.e.m |
100 ± 6 a |
128 ± 3 a, b |
80 ± 4 b |
| ETA (%) ± s.e.m |
100 ± 4 a |
137 ± 3 a, b |
107 ± 4 b |
| TP (%) ± s.e.m |
100 ± 3 |
119 ± 5 |
106 ± 3 |
| AT1 (%) ± s.e.m |
100 ± 2 a |
62 ± 4 a |
82 ± 7 |
| AT2 (%) ± s.e.m |
100 ± 2 a |
120± 2 a |
111 ± 1 |
| 5-HT1B (%) ± s.e.m |
100 ± 6 a |
128 ± 3 a, b |
84 ± 4 b |
| pERK1/2 (%) ± s.e.m | 100 ± 2 a | 128 ± 2 a,b | 86 ± 2 b |
Activation of the different protein levels measured with immunohistochemistry in human arteries. Values are expressed as percentage of control and given as mean ± s.e.m. a = significant difference between organ culture and control groups, b = significant difference between organ culture and organ culture treated with U0126.