Table 1.
KEGG Pathways generated by STRING
| |
|
24 h |
96 h |
1 week |
3 weeks |
||||
|---|---|---|---|---|---|---|---|---|---|
| Pathway ID | Pathway name | # Peptides | p-value (FDR) | # Peptides | p-value (FDR) | # Peptides | p-value (FDR) | # Peptides | p-value (FDR) |
| hsa05221 |
Acute myeloid leukemia |
4 |
0.0227 |
3 |
0.0344 |
2 |
0.228 |
3 |
0.0785 |
| hsa04520 |
Adherens junction |
4 |
0.0506 |
2 |
0.340 |
2 |
0.332 |
4 |
0.0302 |
|
hsa04920 |
Adipocytokine signaling pathway |
6 |
0.0023 |
|
N/S |
4 |
0.0131 |
7 |
0.0003 |
| hsa04360 |
Axon guidance |
6 |
0.0191 |
4 |
0.0432 |
|
N/S |
|
N/S |
| hsa04662 |
B cell receptor signaling pathway |
5 |
0.0123 |
3 |
0.0559 |
|
N/S |
4 |
0.0297 |
| hsa04020 |
Calcium signaling pathway |
5 |
0.166 |
|
N/S |
6 |
0.0095 |
|
N/S |
| hsa04062 |
Chemokine signaling pathway |
4 |
0.469 |
5 |
0.0344 |
4 |
0.126 |
|
N/S |
|
hsa05220 |
Chronic myeloid leukemia |
4 |
0.0452 |
4 |
0.0103 |
2 |
0.318 |
6 |
0.0012 |
| hsa05210 |
Colorectal cancer |
|
N/S |
4 |
0.0066 |
|
N/S |
3 |
0.0969 |
| hsa05213 |
Endometrial cancer |
3 |
0.0976 |
4 |
0.0047 |
|
N/S |
|
N/S |
|
hsa04012 |
ErbB signaling pathway |
8 |
0.0001 |
7 |
0.0000 |
4 |
0.0167 |
5 |
0.0097 |
|
hsa04664 |
Fc epsilon RI signaling pathway |
7 |
0.0006 |
5 |
0.0029 |
|
N/S |
6 |
0.0018 |
| hsa04666 |
Fc gamma R-mediated phagocytosis |
4 |
0.0979 |
4 |
0.0224 |
|
N/S |
5 |
0.0148 |
|
hsa04510 |
Focal adhesion |
8 |
0.0123 |
6 |
0.0115 |
|
N/S |
7 |
0.0154 |
|
hsa05214 |
Glioma |
7 |
0.0001 |
3 |
0.0432 |
6 |
0.0001 |
5 |
0.0033 |
|
hsa00010 |
Glycolysis/Gluconeogenesis |
5 |
0.0064 |
3 |
0.0432 |
3 |
0.0586 |
6 |
0.0008 |
|
hsa04912 |
GnRH signaling pathway |
7 |
0.0015 |
5 |
0.0047 |
4 |
0.0245 |
5 |
0.0151 |
| hsa05410 |
Hypertrophic cardiomyopathy (HCM) |
3 |
0.264 |
|
N/S |
3 |
0.106 |
6 |
0.0018 |
|
hsa04910 |
Insulin signaling pathway |
13 |
0.0000 |
10 |
0.0000 |
7 |
0.0003 |
16 |
0.0000 |
| hsa04730 |
Long-term depression |
4 |
0.0449 |
3 |
0.0537 |
4 |
0.0113 |
|
N/S |
|
hsa04010 |
MAPK signaling pathway |
14 |
0.0001 |
13 |
0.0000 |
4 |
0.318 |
11 |
0.0011 |
|
hsa05218 |
Melanoma |
4 |
0.0443 |
4 |
0.0095 |
4 |
0.0113 |
5 |
0.0043 |
|
hsa04150 |
mTOR signaling pathway |
6 |
0.0004 |
3 |
0.0309 |
|
N/S |
5 |
0.0018 |
|
hsa04722 |
Neurotrophin signaling pathway |
6 |
0.0176 |
6 |
0.0020 |
5 |
0.0113 |
7 |
0.0018 |
|
hsa05223 |
Non-small cell lung cancer |
5 |
0.0048 |
3 |
0.0362 |
|
N/S |
4 |
0.0151 |
|
hsa05212 |
Pancreatic cancer |
4 |
0.0418 |
3 |
0.0476 |
|
N/S |
4 |
0.0227 |
| hsa05200 |
Pathways in cancer |
|
N/S |
|
N/S |
6 |
0.0639 |
9 |
0.0151 |
| hsa04914 |
Progesterone-mediated oocyte maturation |
5 |
0.0176 |
|
N/S |
|
N/S |
5 |
0.0097 |
|
hsa05215 |
Prostate cancer |
5 |
0.0192 |
4 |
0.0173 |
4 |
0.0169 |
5 |
0.0107 |
| hsa04810 |
Regulation of actin cytoskeleton |
6 |
0.104 |
6 |
0.0115 |
|
N/S |
6 |
0.0591 |
|
hsa05211 |
Renal cell carcinoma |
4 |
0.0446 |
5 |
0.0018 |
|
N/S |
4 |
0.0254 |
| hsa05222 |
Small cell lung cancer |
|
N/S |
|
N/S |
2 |
0.397 |
6 |
0.0020 |
| hsa04660 |
T cell receptor signaling pathway |
6 |
0.0123 |
4 |
0.0344 |
|
N/S |
3 |
0.332 |
|
hsa04620 |
Toll-like receptor signaling pathway |
5 |
0.0403 |
5 |
0.0058 |
|
N/S |
6 |
0.0043 |
| hsa04270 |
Vascular smooth muscle contraction |
5 |
0.0452 |
3 |
0.139 |
|
N/S |
4 |
0.105 |
| hsa04370 | VEGF signaling pathway | 6 | 0.0023 | N/S | N/S | 4 | 0.0302 | ||
Peptides that displayed a statistically significant change in phosphorylation state were input into the STRING database for each time point. Generated pathways that displayed a p-value of less than 0.05 (FDR corrected) are listed. Pathways that displayed statistical significance at three or more time points are shown in bold. N/S indicates that the pathway is Non-significant as no peptides were found within the pathway.