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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Mech Ageing Dev. 2013 Feb 19;134(0):275–283. doi: 10.1016/j.mad.2013.02.007

Figure 2. Cockayne syndrome protein B regulates base excision repair.

Figure 2

CSB has been shown to increase the incision activity of OGG1 and NEIL1; two glycosylases responsible for the initial step of removing oxidized lesions such as 8-oxo-G from the ribose backbone. This creates an abasic site that is recognized and removed by APE1 yielding a gab in the DNA strand. APE1 has been shown to physically and functionally interact with CSB. The resulting gap in the DNA is then further processed by short patch or long patch repair involving proteins such as DNA polymerase gamma, DNA ligase III, Fen1 and others.