Table 3.

GEE parameter estimates for Total Bilirubin predicting transplantation or death.

Parameter	Estimate	Odds Ratio	p-value	95% Confidence Limits for Odds Ratio
Placebo 3-4	1.32	3.75	0.0016	1.36	10.36
NAC 3-4	2.28	9.74		2.03	46.61
Placebo 1-2	1.06	2.89		1.25	6.64
NAC 1-2*	0.00	1.00
Day 1	0.27	1.31	0.0290	1.09	1.58
Day 2	0.21	1.24		1.03	1.49
Day 3	0.09	1.09		0.93	1.29
Day 4**	0.00	1.00
Total Bilirubin	0.06	1.06	0.0030	1.02	1.10

Using NAC 1-2 as the reference group, all other groups show positive estimate values indicating higher likelihood of death or transplant. Day 4 is the reference day that is then compared with the prior 3 days. The effect is greatest on day 1 and declines over succeeding days.

^*Reference group for Treatment/Coma combination

^**Reference group for Days 1-3