Table 3.

Results of serologic studies comparing peanut allergic subjects with or without treatment related reactions.

	Not Reactive		Reactive
Variable	Baseline (N=5)	Week 20 (N=5)	Baseline (N=5)	Week 20 (N=4)	P Value
ImmunoCAP IgE (kUA/L) (Median Values)
Peanut	17.17	19.82	82.35	56.62	0.03
Ara h 1	10.28	…	25.48	…	0.15
Ara h 2	8.27	…	43.26	…	0.03
Ara h 3	1.75	…	2.87	…	0.42
Total IgE	900.11	…	381.97	…	0.31
ImmunoCAP IgG4 (mgA/L) (Median Values)
Peanut	2.23	2.13	5.20	1.60	0.22
Ara h 1	0.15	…	0.34	…	0.25
Ara h 2	0.19	…	0.47	…	0.03
Ara h 3	0.06	…	0.08	…	0.11
ELISA (OD@405nm) (Mean Values)
Native Ara h 1	0.80	0.62	1.59	1.80	0.056
Native Ara h 2	0.48	0.35	1.44	1.51	0.03
Wild type Ara h 1	0.16	0.14	0.18	0.18	0.34
Wild type Ara h 2	0.31	0.25	0.90	0.95	0.03
Wild type Ara h 3	0.08	0.08	0.34	0.33	0.008
Modified Ara h 1	0.12	0.13	0.20	0.21	0.15
Modified Ara h 2	0.09	0.11	0.19	0.16	0.15
Modified Ara h 3	0.10	0.10	0.37	0.35	0.056

Notes:

- Wild type refers to recombinant, unmodified proteins.

- P-value reflects comparison of not reactive to reactive at baseline using the exact Wilcoxon test.

- Results for wild type, native, and modified proteins represent OD assessments at 1:100 dilutions

- Ara h 1, Ara h 2, and Ara h 3 were analyzed with ImmunoCAP at baseline only and not at Week 20.