Figure 5.

Adoptive transfer of WT marrow into Mtg16^−/− mice is incapable of rescuing the Mtg16^−/− colonic injury phenotype. Mtg16^−/− (n=6) or WT (n=6) mice were lethally irradiated and rescued with isogenic WT marrow. Three months post-transplantation mice were treated with 3% dextran sodium sulphate (DSS) ad lib for 4 days followed by 3 days of recovery on water. Weights are shown in (A). H&E stained Swiss-rolled sections are shown in (B). Histological injury score was tallied using a multipoint scale²¹ and is presented in (C) (*p<0.05, ***p<0.001: DSS compared with Control, ¶ p<0.05: Mtg16^−/− DSS compared with WT DSS).