Skip to main content
. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Antiviral Res. 2013 Apr 8;98(3):432–440. doi: 10.1016/j.antiviral.2013.03.023

Table 2.

in vitro ADME properties

Aqueous solubility (μM) Plasma protein binding (% bound) CYP inhibition* Caco-2 permeability Liver microsome metabolic stability (% remaining)
pH 4.0 pH 7.4 human rat mouse IC50 Efflux ratio human rat mouse
IHVR11029 296 292 74 68 77 >10μM 4.7 91 79 91
IHVR17028 299 311 88 86 83 >10μM 31.7 42 27 59
IHVR19029 309 303 82 54 51 >10μM 34.2 93 92 87
*

Inhibition of each of the 5 CYP isozymes with 10μM of test compounds.