Table 3.

Inhibition of ER α-glucosidase I in in vitro enzymatic assay

compound	CM-10-18	IHVR-11029	IHVR-17028	IHVR-19029
IC50 (μM)	0.54±0.12	0.09±0.02*	0.24±0.08**	0.48±0.17

Enzyme: rat ER α-glucosidase I;

Substrate: Glc₃Man₅GlcNAc₁

IC₅₀s are expressed as average ± standard deviation from triplicate experiments.

^*P=0.003, compared to CM-10-18

^**P=0.02, compared to CM-10-18.