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Western blotting demonstrates the importance of osteoblastic Pyk2 expression on Mdm2 and p53 expression. Mdm2 and p53 protein levels were significantly reduced in OBs following co-culture with MKs for 5 days. Pyk2 deficiency ameliorates MK-induced reductions in Mdm2 and p53 expression. Representative blot from 3 experiments conducted.
