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. Author manuscript; available in PMC: 2014 May 23.
Published in final edited form as: J Med Chem. 2013 May 3;56(10):3820–3832. doi: 10.1021/jm400349k

Table 2.

Trypanosoma brucei growth inhibition data of diverse analogs 10a-10k.

graphic file with name nihms-471692-f0017.jpg
Compd R1 Tbb EC50 (μM)a,b
10a graphic file with name nihms-471692-t0018.jpg 1.39
10b graphic file with name nihms-471692-t0019.jpg 2.27
10c graphic file with name nihms-471692-t0020.jpg 3.85
10d graphic file with name nihms-471692-t0021.jpg 4.21
10e graphic file with name nihms-471692-t0022.jpg 4.50
10f graphic file with name nihms-471692-t0023.jpg 4.53
10g graphic file with name nihms-471692-t0024.jpg 5.3
10h graphic file with name nihms-471692-t0025.jpg 5.98
10i graphic file with name nihms-471692-t0026.jpg 6.45
10j graphic file with name nihms-471692-t0027.jpg 22.63
a

All EC50 values are ± 7%.

b

Concentration giving 50% inhibition of growth of T brucei brucei Lister 427 cells