Table 7.
Desirable ranges for CNS penetration and the MPO scoring for 23a.
| Prop | Targeted Value | Properties of 23a | MPO Score |
|---|---|---|---|
| cLogP | ≤ 3 | 7.1 | 0 |
| cLogD | ≤ 2 | 7.1 | 0 |
| TPSA | 40 < X ≤ 90 | 59.5 | 1.00 |
| MW | ≤ 360 | 541 | 0 |
| HBD | ≤ 0.5 | 1 | 0.8 |
| pKa | ≤ 8 | 3.05 | 1.0 |
| MPO score | 2.8 | ||
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