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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Ann N Y Acad Sci. 2013 Mar 25;1285(1):59–79. doi: 10.1111/nyas.12045

Figure 4.

Figure 4

The BCL-2 family in hematopoiesis. The proteins of the BCL-2 family contribute to numerous steps of both the innate and adaptive immune system development. The adaptive immune system originates from common lymphoid progenitors (CLP) and is comprised of B cells and T cells. The BCL-2 family is a critical regulator of most of the lymphocyte differentiation stages (e.g., the positive and negative selections, in which double positive (DP) cells are maturated in single positive (SP) cells, or the differentiation into memory lymphocytes). The innate immune system originates from common myeloid progenitors (CMP) and, similarly, differentiation of the myeloid cells is controlled by the BCL-2 family. Numbers in brackets refer to the bibliography.