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. Author manuscript; available in PMC: 2014 Jun 21.
Published in final edited form as: Phys Chem Chem Phys. 2013 Feb 28;15(23):8868–8877. doi: 10.1039/c3cp00017f

Fig. 2.

Fig. 2

Computational models of Aβ channels using truncated (A–D) and full-length Aβ peptides (E,F). In the truncated Aβ channels, the β-strands are arranged in a conventional β-sheet without tilt for the (A) Aβ17–42 (p3) and (B) Aβ9–42 (N9) channels, and in a β-barrel topology with tilt for the (C) p3 and (D) N9 barrels. Full-length Aβ1–42 peptides are arranged in a β-barrel topology with tilt for the (E) conformer 1 and (F) conformer 2 Aβ1–42 barrels. The Aβ channels consist of the U-shaped peptides with the β-strand-turn-β-strand motif. The Aβ17–42 and conformer 1 Aβ1–42 peptides contain the turn at Ser26-Ile31, and the Aβ9–42 and conformer 2 Aβ1–42 peptides contain the turn at Asp23-Gly29.