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NMR-based monomer conformations of Aβ1–42 peptides (A) in an apolar microenvironment (pdb id: 1IYT) and (B) in solution with the appropriate amount of HFIP (pdb id: 1Z0Q), and (C) Aβ1–40 peptide in an aqueous environment (pdb id: 2LFM).