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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Int J Cancer. 2013 Mar 16;133(3):624–636. doi: 10.1002/ijc.28070

Figure 1.

Figure 1

Tumor cells treated with docetaxel show increased surface expression of CRT, but do not undergo ICD. Four human tumor cell lines were treated with 2.5–250 ng/ml (black bars), or 3500 ng/ml docetaxel (open bars). Mitoxantrone (1 μM) was used as a positive control (crosshatched bars). After 72 h of incubation, cells were examined for cardinal signs of ICD. (A) Surface expression of CRT. (B) HMGB1 secretion. (C) ATP secretion. (D) Percentage of dying cells (7AAD+). * = statistical significance relative to untreated cells. This experiment was repeated 2 times with similar results.