Table 2.

Results of association testing using the multiple regression approach with seven functional SNPs

(A) Multiple regression analysis testing overall genetic model with seven SNPs
	Phenotype
	Anxioustemperament	Hippocampus	Amygdala
	P =	P =	P =
Additive	0.043	0.0017	NS
D-major	0.017	0.003	NS
D-minor	0.032	0.0024	NS

(B) Multiple regression results for seven functional SNPs tested simultaneously
	Phenotype
	AnxiousTemperament		Hippocampus
SNP4805	0.014	D-minor	0.017	D-minor
SNP5043	0.0003	D-major	0.03	D-major
SNP5094	0.041	D-minor	NS
SNP5886	NS		NS
SNP8689	NS		NS
SNP9009	NS		NS
SNP9026	NS		NS

Abbreviation: SNP, single nucleotide polymorphism.

Using a multiple regression approach after taking linkage disequilibrium into account, seven putatively functional SNPs were assessed for association with anxious temperament (AT), hippocampal metabolism or metabolism in the central amygdala. (A) The significance of the full model for each of three alternative models (additive, dominance-major (D-major) and dominance-minor (D-minor)) was assessed for each phenotype of interest. (B) The partial regressions (SNPs) were assessed for those phenotypes in which the full model was significant (AT and hippocampus). No partial regression results (SNPs) were considered for amygdale metabolism because the overall model was not statistically significant.

Bolded P-values represent P≤0.05.