Skip to main content
. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: J Bone Miner Res. 2013 Jun;28(6):1412–1421. doi: 10.1002/jbmr.1871

Fig. 6.

Fig. 6

Altered chondrocyte gene expression in Snai1/Snai2 DM femurs. In situ hybridization of femurs isolated at E14.5 (A–F) and E16.5 (G–T). At E14.5, Snai1/Snai2 DM femurs exhibited reduced expression of Col10a1 (a hypertrophic chondrocyte marker) (C, D) and Indian hedgehog (Ihh) (a prehypertrophic chondrocyte marker) (E, F). Expression of the Col10a1 (I, J) and Ihh (M, N) genes had recovered in DM femurs at E16.5. Expression of the Mmp9 (Q, R) and Mmp13 (S, T) genes (encoding matrix metalloproteases) was strongly decreased in DM femurs at E16.5. PC: proliferating chondrocytes; HC: hypertrophic chondrocytes.