Table 2.
Results of the three primary regression analyses for entorhinal cortex volume and hippocampus volume. Model 1 includes AD-related biological markers as primary predictors and cranial volume, age, and sex as additional covariates. Model 2 includes the regional WMH volumes as predictors along with the same covariates. Model 3 includes all predictors and covariates together. Model 4 is the same as Model 3 but is restricted to the 86 MCI patients who progressed to AD during the subsequent follow-up visits. For Model 4, number of months to “conversion” was included as an additional covariate. Values are standardized beta (p-value)
| Dependent Variable |
Predictors | Model 1 | Model 2 | Model 3 | Model 4 |
|---|---|---|---|---|---|
| Entorhinal cortex volume |
Aβ1–42 | 0.193 (0.014) | -- | 0.148 (0.058) | −0.071 (0.545) |
| p-tau | −0.015 (0.847) | -- | −0.030 (0.699) | 0.074 (0.534) | |
| Total cranial volume |
0.215 (0.015) | 0.276 (0.02) | 0.258 (0.005) | 0.397 (0.014) | |
| Age | −0.163 (0.021) | −0.101 (0.166) | −0.112 (0.123) | −0.008 (0.947) | |
| Sex (1=female, 2=male) |
−0.116 (0.192) | −0.110 (0.213) | −0.101 (0.252) | 0.038 (0.799) | |
| Frontal WMH | -- | 0.090 (0.402) | 0.079 (0.455) | 0.162 (0.317) | |
| Temporal WMH |
-- | −0.267 (0.035) | −0.248 (0.048) | −0.484 (0.015) | |
| Parietal WMH | -- | 0.070 (0.594) | 0.057 (0.662) | 0.224 (0.241) | |
| Occipital WMH |
-- | −0.102 (0.371) | −0.078 (0.498) | 0.091 (0.617) | |
| Months to conversion |
-- | -- | -- | 0.056 (0.605) | |
| Hippocampus volume |
Aβ1–42 | 0.145 (0.046) | -- | 0.118 (0.110) | −0.155 (0.129) |
| p-tau | −0.038 (0.604) | -- | −0.048 (0.512) | 0.082 (0.432) | |
| Total cranial volume |
0.318 (<0.001) |
0.351 (<0.001) |
0.351 (<0.001) |
0.618 (<0.001) | |
| Age |
−0.369 (<0.001) |
−0.319 (<0.001) |
−0.330 (<0.001) |
−0.172 (0.102) | |
| Sex (1=female, 2=male) |
−0.006 (0.944) | −0.028 (0.740) | −0.006 (0.944) | 0.107 (0.408) | |
| Frontal WMH | -- | 0.010 (0.921) | −0.005 (0.956) | 0.080 (0.567) | |
| Temporal WMH |
-- | −0.178 (0.135) | −0.148 (0.209) | −0.334 (0.051) | |
| Parietal WMH | -- | 0.047 (0.700) | 0.053 (0.665) | 0.131 (0.427) | |
| Occipital WMH |
-- | −0.049 (0.649) | −0.047 (0.661) | 0.048 (0.760) | |
| Months to conversion |
-- | -- | -- | 0.166 (0.077) |