Table 3.
Comparison of our data and data in the literature
| Our data | Azzarello et al. [3] | Ciray et al. [4] | Meseguer et al. [10] | Dal Canto et al. [6] | Kirkegaard et al. [8] | |||
|---|---|---|---|---|---|---|---|---|
| MKP | IVD/IMP* | IMP | IMP | IMP | IVD | IMP | IVD | |
| Type of data | Mean/Median (cc3) | Inferior limit | Mean | Mean | Mean | Mean | Mean | Median (95 % CI) |
| n emb. | 72 | 37 | 9 | 9 | 61 | 93 | 19 | 53 |
| tC-tF | 15.1 (7.7–22.9) | − | − | − | − | − | − | |
| t1 | 24.1 (18.4–30.9) | 20.75 | − | − | − | − | − | |
| t2 | 26.9 (21.4–34.8) | − | 24.7 ± 3.6 | 27.9 ± 3.4 | 25.6 ± 2.2 | 27.9 ± 4.1 | 26.1 (25.2–26.9) | |
| t3 | 38.3 (27.8–47.8) | − | 35.7 ± 5.1 | 40.1 ± 4.1 | 37.4 ± 2.8 | 37.9 ± 4.6 | 35.7 (34.3–37.3) | |
| t4 | 40.3 (33.1–57.2) | − | 36.6 ± 4.3 | 41.4 ± 4.5 | 38.2 ± 3.0 | 40.2 ± 5.8 | 37.6 (35.9–39.3) | |
| t5 | 53.0 (37.5–67.0) | − | 47.4 ± 7.9 | 53.9 ± 6.0 | 52.3 ± 4.2 | 50.2 ± 6.7 | 49.4 ± 4.9 | 49.6 (47.3–52.0) |
| t6 | 54.3 (46.1–73.5) | − | − | − | − | 53.9 ± 7.6 | 52.4 (50.1–54.9) | |
| t7 | 57.4 (46.1–82.5) | − | − | − | − | 58.8 ± 10.4 | 58.0 (55.5–60.5) | |
| t8 | 61.0 (46.4–97.8) | − | − | − | − | 65.2 ± 13.0 | 54.9 ± 5.2 | 60.5 (57.8–63.4) |
| cc2 | 11.4 (1.3–14.7) | − | 11.1 ± 2.4 | 12.2 ± 1.1 | 11.8 ± 1.2 | 10.6 ± 1.8 | − | |
| cc3 | 14.4 (9.7–21.0)* | − | − | − | − | − | − | |
| s2 | 2.0 (0–15.7) | − | 0.9 ± 1.5 | 1.2 ± 1.3 | 0.78 ± 0.73 | 2.3 ± 3.6 | − | |
| s3 | 8.0 (0.7–30.8) | − | − | − | − | 14.9 ± 10.7 | − | |
| CO2 % | 5 | 5.5 | 6 | 6 | 5 | 6 | 6 | |
| O2 % | 5 | 5 | 5 | 5 | 20 | 5 | 20 | |
| Medium | SAGE | COOK | Irvine (single) | Irvine (Seq) | SAGE | Origio | COOK | |
| Day of transfer | 5 | 2 | 4 | 4 | 3 | 3 | − | |
IVD in vitro development until day 5; Single single step medium; Seq sequential medium
All data are expressed in hour and fraction of an hour. The significant data are in bold