(A) Relapse-free survival of all 340 patients with melanoma substages IIIA, IIIB, and IIIC who relapsed. Relapse-free survival was estimated separately for patients with substages IIIA (B), IIIB (C), and IIIC (D) by anatomic site of first relapse. (E) Site of first relapse and method of its detection. Local and in-transit recurrences are combined. LN, lymph node.