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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Glia. 2012 Apr 25;60(7):1172–1181. doi: 10.1002/glia.22344

Fig. 3. Immunogold electron microscopy of monocarboxylate transporter 2 (MCT2) on perivascular astrocyte endfeet membranes (green) and on astrocyte plasma membranes in the neuropil (yellow).

Fig. 3

Dense labeling of membrane associated MCT2 (red arrowheads) is present along the perivascular astrocyte endfoot facing the basal lamina (stippled line) in non-MTLE (A), whereas labeling of the same compartment is significantly reduced in MTLE (C). MCT2 labeling is also found on astrocytes plasma membranes in the neuropil, and to a lesser extent on organelles in the cytoplasm of these cells (B, D). Compared to non-MTLE (B), the density of MCT2 on plasma membranes of astrocytes in the neuropil is significantly upregulated in MTLE (stippled line in D). Abbreviations: astro, astrocytes; AT, axon terminal; bl, basal lamina; end, endothelial cell; lu, lumen; m, mitochondria. Arrow, bundle of intermediate filaments. Bars: 500 nm.