Table 4.
Primary endpoint complications as well as secondary endpoints after liver resection as the second stage of a two-stage hepatectomy compared with resection in one stage expressed as an odds ratio or difference between values, adjusted in a multivariate regression model
| Odds ratio or difference for two-stage hepatectomy versus one-stage hepatectomy in multivariate regression model | ||
|---|---|---|
| Unadjusted odds ratio (95% CI, P-value) | Adjusted odds ratio (95% CI, P-value) | |
| Post-operative complications overalla | 1.3 (0.6–3.0, P = 0.47) | 0.9 (0.36–2.17, P = 0.79) |
| Severe complications ≥ IIIAa | 0.9 (0.37–1.96, P = 0.71) | 0.5 (0.17–1.30, P = 0.14) |
| Post-operative liver failureb | – | – |
| Mortality during hospitalization (Grade V)b | – | – |
| 30 day mortalityb | – | – |
| 90 day mortality | 2.8 (0.9–9.0, P = 0.079) | 3.7 (0.9–15.2, P = 0.066) |
| Unadjusted difference (95% CI, P-value) | Adjusted difference (95% CI, P-value) | |
| AST peak (U/l) | 86.6 (−89.8–263.1, P = 0.33) | −11.4 (−204.5–181.6, P = 0.91) |
| ALT peak (U/l) | −1.54 (−171.4–174.5, P = 0.99) | −78.0 (−269.0–113.0, P = 0.42) |
| Bilirubin peak (μmol/l) | 5.3 (−19.5–30.1, P = 0.68) | 11.8 (−16.8–40.4, P = 0.42) |
| Creatinine peak (μmol/l) | 9.4 (−6.8–25.6, P = 0.25) | 3.6 (−13.9–21.2, P = 0.68) |
| Length of hospital stay (days) | 4.1 (1.2–6.9, P = 0.005) | 1.9 (−1.0–4.9, P = 0.20) |
| Special care unit stay (days) | 0.86 (−0.8–2.5, P = 0.30) | 0.3 (−1.4–2.1, P = 0.70) |
| Blood loss (ml) | 51.0 (−254.9–357.0, P = 0.74) | −54.7 (−395.3–285.8, P = 0.75) |
| Blood transfusion (%) | 2.0 (0.77 −5.27, P = 0.15) | 2.3 (0.42–12.98, P = 0.34) |
All results are presented in median (interquartile range).
All results are adjusted for possible confounders such as gender, pre-operative chemotherapy (no/yes), ASA score (≤2/ > 2), liver steatosis (<30%/≥30%), liver fibrosis (no/yes), baseline ALT/AST and bilirubin level, trisectionectomy, blood loss.
ASA, American Society of Anesthesiologists score; AST, aspartate aminotransferase; ALT, alanine aminotransferase.
Complication classification according to the Clavien–Dindo classification system.
Less than five events: therefore no statistical calculation was performed.