Skip to main content
. 2012 Nov 12;10(1):58–64. doi: 10.1038/cmi.2012.46

Figure 1.

Figure 1

Immune responses and functions of HMBPP-specific Vγ2Vδ2 T cells in infections. Shown are drawings describing the following immune events: (i) Vγ2Vδ2 TCR recognition of HMBPP phosphoantigen on the APC surface; (ii) innate immune responses of HMBPP-activated Vγ2Vδ2 T cells; (iii) clonal expansion of Vγ2Vδ2 T cells in response to signals from HMBPP/TCR and cytokines; (iv) trafficking of Vγ2Vδ2 T cells to lungs or mucosal surfaces; (v) evolving T effector functions of producing/coproducing cytokines; (vi) anti-TB or anti-Listeria activities of Vγ2Vδ2 T cells in vitro; (vii) potential in vivo functions of Vγ2Vδ2 T cells against TB; (viii) immune enhancing function of Vγ2Vδ2 T cells. APC, antigen-presenting cell; HMBBP, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate; TB, tuberculosis; TCR, T-cell receptor.