Table 2.
Examples of as-yet-uncultivated/uncharacterized oral bacteria found in association with diseased sites
| As-yet-uncultivated/uncharacterized phylotypes (HOMD classification) | Synonym | GenBank accession no. | Oral condition | Study |
|---|---|---|---|---|
| Actinobacteria | ||||
| Actinobaculum sp. HOT-1831 | Actinobaculum oral clone EL030 | AY008311 | Root caries | (66, 100) |
| Root canal | ||||
| Actinomyces sp. HOT-1691 | Actinomyces oral clone AG004 | AF287747 | Caries | (69) |
| Actinomyces sp. HOT-1701 2 | Actinomyces oral clone AP064 | AF287749 | Caries | (69, 151) |
| Root canal | ||||
| Actinomyces sp. HOT-1751 | Actinomyces oral clone GU067 | GU407261 | Caries | (67) |
| Actinomyces sp. HOT-4482 | Actinomyces oral clone IP073 | AY349365 | Root caries | (66) |
| Atopobium sp. HOT-1991 | Atopobium oral clone C019 | AF287760 | Root canal | (152) |
| Atopobium sp. HOT-4161 2 | Atopobium genomospecies C1 | AY278623 | Caries | (67, 73, 93, 94, 148) |
| Root canal | ||||
| Bacteroidetes | ||||
| Bacteroidaceae sp. HOT-2721 | Bacteroidetes oral clone X083 | AY005066 | Root canal Extraradicular infection Periodontal disease | (47, 93, 94, 98, 104, 148, 149, 153, 154) |
| Bacteroidales sp. HOT-2741 2 | Bacteroidetes oral clone AU126 | AY005072 | Periodontal disease Root canal Extraradicular infection | (82, 86, 148, 149, 155) |
| Bacteroidetes sp. HOT-3651 | Bacteroidales oral clone E2b MCE7_164 | AF481206 | Root canal | (55, 93, 98, 154) |
| Prevotella sp. HOT-3041 | Prevotella oral clone DA058 | AY005065 | Root canal Peri-implantitis | (88, 156) |
| Prevotella sp. HOT-3061 | Prevotella oral clone DG059 | GU409581 | Caries Root canal | (69, 157) |
| Prevotella sp. HOT-4721 | Prevotella oral clone GU027 | GU413272 | Root canal | (56, 152) |
| Firmicutes | ||||
| Erysipelotrichaceae sp. HOT-9041 | Solobacterium oral clone 6Ta-2 | AB256031 | Root canal | (94, 152) |
| Lachnospiraceae sp. HOT-0861 | Eubacterium oral clone BU061 | AF385567 | Root canal | (98, 156) |
| Lachnospiraceae oral clone 55A-34 (no HOMD)1 | Lachnospiraceae oral clone 55A-34 | AB213385 | Root canal Peri-implantitis | (88, 93, 105, 110) |
| Megasphaera sp. HOT-1231 2 | Megasphaera oral clone CS025 | AF287784 | Root canal Periodontal disease | (91, 93) |
| Mitsuokella sp. HOT-1311 2 | Selenomonas oral clone CS002 | AF287795 | Root caries Root canal | (66, 156) |
| Moryella sp. HOT-3731 | Lachnospiraceae oral clone E4 MCE9_173 | AF481221 | Root canal | (55, 98, 152, 154) |
| Oribacterium sp. HOT-1021 | Lachnospiraceae oral clone E1 MCE7_60 | AF481218 | Root canal | (55, 93, 94, 98) |
| Peptostreptococcaceae sp. HOT-1031 2 | Eubacterium oral clone PUS9.170 | AJ012604 | Periodontal disease Root canal | (47, 98, 158, 159) |
| Peptostreptococcaceae sp. HOT-3831 | Eubacteriaceae oral clone P3 P2PB_46 | AF538856 | Root canal | (98, 148, 154, 156) |
| Selenomonas sp. HOT-1261 2 | Selenomonas oral clone EY047 | AF385576 | Caries | (67) |
| Selenomonas sp. HOT-1462 | Selenomonas oral clone EW084 | AF385503 | Periodontal disease | (83, 85) |
| Selenomonas sp. HOT-1491 | Selenomonas oral clone FT050 | AY349403 | Periodontal disease Root caries Root canal | (66, 83, 156) |
| Streptococcus sp. HOT-0581 2 | Streptococcus oral clone BW009 | AY005042 | Caries Tongue dorsum – halitosis Extraradicular infection | (107, 149, 160) |
| Streptococcus sp. HOT-0641 | Streptococcus genomosp. C8 | AF385574 | Caries | (160) |
| Streptococcus sp. HOT-0711 | Streptococcus genomosp. C3 | AY278631 | Caries | (160) |
| Veillonella sp. HOT-7802 | Veillonella oral clone HB016 | DQ087189 | Caries | (160) |
| Veillonellaceae sp. HOT-1321 | Selenomonas oral clone CS015 | AF287791 | Root canal Peri-implantitis | (88, 97) |
| Veillonellaceae sp. HOT-1552 | Selenomonas oral clone GAA14 | AF287789 | Periodontal disease Root caries | (47, 66) |
| Proteobacteria | ||||
| Desulfobulbus sp. HOT-0411 2 | Desulfobulbus oral clone R004/CH031 | AY005037/AY005036 | Periodontal disease Root canal Peri-implantitis | (47, 79, 84, 90, 94, 98–100, 110, 151) |
| Spirochaetes | ||||
| Treponema sp. HOT-2311 2 | Treponema sp. I:G:T21 | AF023055 | Periodontal disease Root canal | (47, 105) |
| Treponema sp. HOT-2581 | Treponema sp. IV:18:C9 | AF023042 | Root canal | (103) |
| Treponema sp. HOT-2691 2 | Treponema sp. 6:H:D15A-4 | AY005083 | Periodontal disease Root canal | (79, 98, 161) |
| Synergistetes | ||||
| Fretibacterium sp. HOT-3591 2 | Synergistes oral clone BH007 | AY005447 | Periodontal disease Extraradicular infection | (79, 149) |
| Fretibacterium sp. HOT-360/HOT-3621 2 | Synergistes oral clone BH017/D084 | AF125199/AF125200 | Periodontal disease Root canal Extraradicular infection | (47, 82, 86, 90, 98–100, 149) |
| TM7 | ||||
| TM7 sp. HOT-3522 | TM7 oral clone DR034 | AF385520 | Tongue dorsum – halitosis | (107) |
| TM7 sp. HOT-3492 | TM7 oral clone BS003 | AY005448 | Periodontal disease | (90, 91) |
| TM7 sp. HOT-3561 2 | TM7 oral clone I025 | AF125206 | Periodontal disease Root canal Peri-implantitis | (47, 82, 87, 88, 99, 100, 123) |
| SR1 | ||||
| SR1 sp. HOT-3452 | SR1 oral clone X112 | AF125207 | Periodontal disease | (82, 155) |
1
Detected in the diseased site.
2
Higher prevalence/abundance in disease than health.