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. 2013 May 16;21(1):37. doi: 10.1186/2008-2231-21-37

Table 2.

Anticancer activity of M. azedarach and A. indica extracts and fractions on different cell lines

Sample
 Cell lines
MCF7
 HepG2
 A549
 HT29
 MDBK
    IC50* SI IC50 SI IC50 SI IC50 SI IC50
C. Seed E.
 1
 33.41
 1.20
 34.91
 1.15
 60.10
 0.67
 8.18
 4.90
 40.13
2
 270.58
 -
 >650
 -
 370.69
 -
 343.28
 -
 >650
C. Pulp E.
 1
 >650 **
 -
 >650
 -
 >650
 -
 >650
 -
 >650
2
 139
 0.83
 212.16
 0.54
 83.45
 1.38
 83.49
 1.38
 115.47
C. Leaf E.
 1
 >650
 -
 >650
 -
 >650
 -
 218.61
 0.89
 195.8
2
 34.11
 2.06
 95.51
 0.73
 55.84
 1.25
 38.44
 1.82
 70.27
Chloroform F.
 1
 ND
 -
 ND
 -
 ND
 -
 ND
 -
 ND
2
 38.94
 1.13
 74.94
 0.59
 54.59
 0.81
 46.22
 0.95
 44.11
Ethyl acetate F.
 1
 147.9
 0.59
 210.3
 0.42
 146.26
 0.60
 48.91
 1.79
 87.56
2
 56.29
 0.93
 49.11
 1.07
 55
 0.95
 18.63
 2.82
 52.55
Methanol F.
 1
 >1000***
 -
 >1000
 -
 >1000
 -
 >1000
 -
 493.81
 
 2
 >1000
 -
 >1000
 -
 >1000
 -
 >1000
 -
 193.3
Tomoxifen   3.60 1.22 5.8 0.76 10.7 0.41 2.5 1.79 4.4

SI selectivity index, C. crude, E. extract, F. fraction, 1: M. azedarach L., 2: A. indica, ND not detected due to its insolubility;

* IC50 values were calculated in μg mL-1.

** The sample was not toxic in concentrations less than 650 μg mL-1 and insoluble in concentrations more than it.

*** The sample was not toxic in concentrations less than 1000 μg mL-1.