Table 2.
Sample |
Cell lines |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
MCF7 |
HepG2 |
A549 |
HT29 |
MDBK |
||||||
IC50* | SI | IC50 | SI | IC50 | SI | IC50 | SI | IC50 | ||
C. Seed E. |
1 |
33.41 |
1.20 |
34.91 |
1.15 |
60.10 |
0.67 |
8.18 |
4.90 |
40.13 |
2 |
270.58 |
- |
>650 |
- |
370.69 |
- |
343.28 |
- |
>650 |
|
C. Pulp E. |
1 |
>650 ** |
- |
>650 |
- |
>650 |
- |
>650 |
- |
>650 |
2 |
139 |
0.83 |
212.16 |
0.54 |
83.45 |
1.38 |
83.49 |
1.38 |
115.47 |
|
C. Leaf E. |
1 |
>650 |
- |
>650 |
- |
>650 |
- |
218.61 |
0.89 |
195.8 |
2 |
34.11 |
2.06 |
95.51 |
0.73 |
55.84 |
1.25 |
38.44 |
1.82 |
70.27 |
|
Chloroform F. |
1 |
ND |
- |
ND |
- |
ND |
- |
ND |
- |
ND |
2 |
38.94 |
1.13 |
74.94 |
0.59 |
54.59 |
0.81 |
46.22 |
0.95 |
44.11 |
|
Ethyl acetate F. |
1 |
147.9 |
0.59 |
210.3 |
0.42 |
146.26 |
0.60 |
48.91 |
1.79 |
87.56 |
2 |
56.29 |
0.93 |
49.11 |
1.07 |
55 |
0.95 |
18.63 |
2.82 |
52.55 |
|
Methanol F. |
1 |
>1000*** |
- |
>1000 |
- |
>1000 |
- |
>1000 |
- |
493.81 |
|
2 |
>1000 |
- |
>1000 |
- |
>1000 |
- |
>1000 |
- |
193.3 |
Tomoxifen | 3.60 | 1.22 | 5.8 | 0.76 | 10.7 | 0.41 | 2.5 | 1.79 | 4.4 |
SI selectivity index, C. crude, E. extract, F. fraction, 1: M. azedarach L., 2: A. indica, ND not detected due to its insolubility;
* IC50 values were calculated in μg mL-1.
** The sample was not toxic in concentrations less than 650 μg mL-1 and insoluble in concentrations more than it.
*** The sample was not toxic in concentrations less than 1000 μg mL-1.