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. Author manuscript; available in PMC: 2013 May 25.
Published in final edited form as: Clin Trials. 2012 Apr 30;10(1 0):S5–S36. doi: 10.1177/1740774512440342

Table A3.

Parameter estimates for the CD4 trajectory after ART initiation under the full model

Square root CD4 Estimate 95% Confidence interval
Fixed effects
 Mean baseline (A) α 19.69 19.52–19.86
 Mean slope 1 (B) β 2.93 2.80–3.07
 Mean slope 2 (C) γ 0.10 0.04–0.16
Random effects
 SD(A) σa 5.71 5.59–5.84
 SD(B) σb 2.06 1.85–2.30
 Corr(A,B) rab −0.44 −0.50 to −0.37
 SD(C)/SD(A) ψ 0.10 0.09–0.11
Brownian motion
 Variance at 1 year δ 7.83 7.52–8.15
Measurement error
 SD(E) σe 2.19 2.17–2.21

CD4: CD4+ T lymphocyte; ART: antiretroviral treatment; SD: standard deviation.