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. Author manuscript; available in PMC: 2014 Jun 15.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Mar 30;23(12):3654–3661. doi: 10.1016/j.bmcl.2013.02.096

Table 3.

IC50 values (nM) against Clk and Dyrk kinases for small-molecule inhibitors

Compound Clk1 Clk2 Clk3 Clk4 Dyrk1A Dyrk1B
35 (ML315) 68 231 >10,000 68 282 1156
139 59 1902 6936 39 62 697
243 1522 1648 >10,000 136 >10,000 4420
TG00339 19 95 3000 30 12 130
KH-CB1917 20 NR* 530 NR* 55 NR*
Leucettine L4118 15 NR* 4500 NR* 40 NR*
*

NR = not reported