Table 4.
Clinical features in different genotype groups
|
Genotype |
Hearing level |
CT |
Vertigo | |||||
|---|---|---|---|---|---|---|---|---|
| Normal | Mild | Moderate | Severe | Profound | MD | VE | ||
| IVS15 + 5 G > A homozygous (n = 6) |
0 |
0 |
0 |
3 |
9 |
6/12 |
6/12 |
4/6 |
| H723R homozygous (n = 5) |
0 |
0 |
0 |
1 |
9 |
4/10 |
3/10 |
0/5 |
| IVS15 + 5 G > A/H723R (n = 9) |
0 |
1 |
2 |
4 |
11 |
5/18 |
11/18 |
4/9 |
| IVS15 + 5G > /T527P (n = 1) |
0 |
0 |
0 |
1 |
1 |
2/2 |
1/2 |
0/1 |
| No mutation (n = 1) |
1 |
0 |
1 |
0 |
0 |
0/2 |
0/2 |
0/1 |
| Subtotal |
1 |
1 |
3 |
9 |
30 |
17/44 | 21/44 | 8/22 |
| Total | 44 | |||||||
Normal: ≤20 dB; Mild: 21–40 dB; Moderate: 41–70 dB; Severe: 71–90 dB; Profound: >91 dB.
MD Mondini malformation, VE Vestibular enlargement, CT computed tomography.