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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: J Immunol. 2013 Mar 25;190(9):4508–4515. doi: 10.4049/jimmunol.1202923

FIGURE 5.

FIGURE 5

PDK1 PH domain inhibits PDK1-mediated NF-κB activation in T cells. A, The effect of PDK1 PH domain expression on PDK1-PKCθ-CARMA1-Bcl10-Malt1-mediated NF-κB activation was determined by NF-κB-reporter assay. B and C, The effect of PDK1 PH domain expression on TCR-CD28-mediated NF-κB activation in mouse primary CD4+ T cells (B) or Jurkat T cells (C) was determined by NF-κB reporter assay. The Renilla luciferase activity was used as a reference for normalization of gene expression in transiently transfected cells. Results: mean ± SD. Student’s t test: *, p < 0.05; **, p < 0.01.