Table 1.
Demographics, socioeconomics and HIV-related characteristics
| HIV-infected (at week 144 of PREDICT) |
HIV-uninfected | |||
|---|---|---|---|---|
| Early ART (n=139) |
Deferred ART (n=145) |
HIV exposed (n=155) |
HIV unexposed (n=164) |
|
| Demographic and socioeconomic characteristics | ||||
| Median age | 9 years | 9 years | 7 years** | 7 years** |
| Age, n | ||||
| < 5 years | 14 | 13 | 40** | 38** |
| 5 to 12 years | 106 | 106 | 96 | 112 |
| > 12 years | 19 | 26 | 19 | 14 |
| Female | 51% | 64% | 57% | 58% |
| Thai | 60% | 59% | 63% | 66% |
| Father or mother as primary caregiver |
65% | 64% | 93%** | 87%** |
| Caregiver education; high school/bachelor |
43% | 43% | 34% | 65%** |
| Low/very low income | 59% | 66% | 58% | 35%** |
| HIV-related characteristics | ||||
| CDC N:A:B | 1:61:38% | 1:63:36% | ||
| Time on ART (weeks) | 144 weeks | 48% on ART for a median of 81 weeks |
||
| Median current CD4% | 33% | 24%** | ||
| Median current CD4 count (cells/mm3) |
978 | 653** | ||
| Median %CD4 nadir | 18% | 15%** | ||
| %HIV RNA < 50 copies/ml | 91% | 40%** | ||
Footnote: p value < 0.001
Characteristics at time of primary neurocognitive endpoint (week 144 of PREDICT) are shown here for the HIV-infected children in the randomized early and deferred antiretroviral therapy (ART) arms. The two HIV-uninfected groups had a cross-sectional neurodevelopmental assessment, and their characteristics at time of enrollment are included.
The significant p values for the demographic and socioeconomic characteristics denote significant differences between each of the HIV-uninfected groups with the combined HIV-infected groups. Exceptions are caregiver’s education and low/very low income in which only the HIV-unexposed uninfected group is significantly different to the other 3 groups. For HIV-related characteristics, the p value denotes significant differences between the early and deferred HIV-infected arm.