Table 2.
Mean differences (95%CI) in neurodevelopmental test score at week 144 between deferred and early treatment arms, and between all HIV-infected PREDICT children versus the HIV-exposed/uninfected and HIV-unexposed/uninfected controls
| Deferred VS early | Predict VS exposed* |
Predict VS unexposed* |
||||
|---|---|---|---|---|---|---|
| Diff 95%CI | P | Diff 95%CI | P | Diff 95%CI | P | |
| Intelligence quotient (IQ) | ||||||
| Full Scale IQ | −0.78 (−5.02,3.46) | 0.72 | −9.03(−13.04,−5.01) | <0.001 | −12.45(−16.91,−7.98) | <0.001 |
| Verbal IQ | −0.15 (−3.95,3.65) | 0.94 | −9.25(−12.91,−5.58) | <0.001 | −14.85(−19.06,−10.64) | <0.001 |
| Performance IQ | −0.42 (−5.12,4.27) | 0.86 | −6.71(−11.15,−2.28) | 0.003 | −9.04(−13.95,−4.13) | <0.001 |
| Processing speed quotient | −0.5 (−5.57,4.56) | 0.84 | −10.15(−15.17,−5.13) | <0.001 | −12.99(−18.48,−7.50) | <0.001 |
| Binet memory | ||||||
| Beads | −2.04 (−4.68,0.6) | 0.13 | −0.71(−3.27,1.86) | 0.59 | −2.18(−4.93,0.58) | 0.12 |
| Objects | 2.27 (0.17,4.38) | 0.04 | 0.03(−2.03,2.09) | 0.98 | −0.68(−3.04,1.67) | 0.569 |
| Digits | −0.31 (−2.35,1.73) | 0.77 | −2.70(−4.78,−0.63) | 0.01 | −4.08(−6.39,−1.76) | 0.001 |
| Sentences | −0.29 (−1.84,1.25) | 0.71 | −2.39(−3.93,−0.85) | 0.002 | −4.03(−5.96,−2.11) | <0.001 |
| Fine motor | ||||||
| Beery visual motor integration |
1.01 (−2.3,4.32) | 0.55 | −8.41(−11.25,−5.57) | <0.001 | −10.56(−13.72,−7.39) | <0.001 |
| Color Trail 1 standard score |
1.1 (−3.99,6.2) | 0.67 | 0.66(−4.54,5.85) | 0.80 | −0.81(−6.46,4.83) | 0.78 |
| Color Trail 2 standard score |
2.33 (−2.26,6.91) | 0.32 | −0.15(−4.74,4.45) | 0.95 | 2.49(−2.73,7.71) | 0.35 |
| Purdue pegboard dominant hand pin placements† |
0.12 (−0.39,0.63) | 0.64 | 0.98(0.49,1.46) | <0.001 | 0.74(0.24,1.24) | 0.004 |
| Purdue pegboard non- dominant hand pin placements† |
0.24 (−0.29,0.76) | 0.37 | 0.79(0.30,1.28) | 0.002 | 0.48(−0.01,0.97) | 0.06 |
| Behaviour | ||||||
| CBCL total problem T score |
0.91 (−1.33,3.14) | 0.42 | 0.94(−1.10,2.99) | 0.37 | 2.35(0.21,4.49) | 0.03 |
| CBCL internalized problem T score |
0.99 (−1.18,3.16) | 0.37 | 1.92(−0.13,3.98) | 0.066 | 0.85(−1.20,2.89) | 0.42 |
| CBCL externalized problem T score |
0.01 (−2.17,2.2) | 0.99 | 2.44(0.47,4.41) | 0.015 | 3.25(1.20,5.30) | 0.002 |
Footnote: CBCL: Child behaviour checklist
*
Significant differences are between each of the HIV-uninfected groups relative to the combined early and deferred groups. Comparisons with HIV-uninfected control groups are adjusted for differences between groups (parent as caregiver, educational level of caregiver and income).
†
Purdue Pegboard pin placements are raw scores adjusted for age and gender.