Table 2.
Multivariate analysis using a Cox proportional Hazards Model for (A) Disease-free and (B) Melanoma-specific survival.
| (A)
| |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | Level | Total (Events) | Univariate Hazard Ratio | Univariate 95% CI | Univariate p-value | Total (Events) | Multivariable Hazard Ratio | Multivariable 95% CI | Multivariable p-value |
| Treatment | GMCSF | 152 (87) | 1.14 | (0.84,1.55) | 0.384 | ||||
| Observation | 165 (80) | 1.0 (Ref) | - | - | |||||
| Sex | Female | 113 (47) | 1.0 (Ref) | - | - | 85 (29) | - | - | |
| Male | 204 (120) | 1.72 | (1.23,2.42) | 0.002 | 181 (108) | 2.38 | (1.56,3.64) | <0.001 | |
| Age | per year | 317 (167) | 1.01 | (1.00,1.02) | 0.008 | 266 (137) | 1.01 | (1.00,1.02) | 0.047 |
| Stage | IIIA | 101 (35) | 1.0 (Ref) | - | - | 97 (33) | - | - | |
| IIIB | 127 (67) | 1.89 | (1.25,2.85) | 0.002 | 103 (58) | 2.20 | (1.43,3.40) | <0.001 | |
| IIIC | 89 (65) | 3.81 | (2.52,5.77) | <0.001 | 66 (46) | 3.96 | (2.48,6.33) | <0.001 | |
| ECOG Category | 0 | 267 (132) | 1.0 (Ref) | - | - | ||||
| ≥1 | 34 (21) | 1.50 | (0.94,2.38) | 0.087 | |||||
| Breslow Depth | per mm | 266 (137) | 1.11 | (1.06,1.17) | <0.001 | 266 (137) | 1.06 | (1.01,1.13) | 0.031 |
| Recurrence prior to adjuvant therapy | No | 252 (122) | 1.0 (Ref) | - | - | ||||
| Yes | 65 (45) | 1.59 | (1.13,2.24) | 0.008 | |||||
| Radiation | No | 264 (132) | 1.0 (Ref) | - | - | ||||
| Yes | 53 (35) | 1.72 | (1.18,2.50) | 0.005 | |||||
| (B)
| |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | Level | Total (Events) | Univariate Hazard Ratio | Univariate 95% CI | Univariate p-value | Total (Events) | Multivariable Hazard Ratio | Multivariable 95% CI | Multivariable p-value |
| Treatment | GMCSF | 152 (42) | 0.70 | (0.47,1.04) | 0.079 | ||||
| Observation | 165 (58) | 1.0 (Ref) | - | - | |||||
| Sex | Female | 113 (21) | 1.0 (Ref) | - | - | 85 (14) | - | - | |
| Male | 204 (79) | 2.56 | (1.58,4.15) | <0.001 | 181 (71) | 2.45 | (1.35,4.43) | 0.003 | |
| Age | per year | 317 (100) | 1.02 | (1.01,1.04) | <0.001 | 266 (85) | 1.03 | (1.01,1.04) | 0.002 |
| Stage | 3A | 101 (23) | 1.0 (Ref) | - | - | 97 (21) | - | - | |
| 3B | 127 (31) | 1.17 | (0.68,2.00) | 0.576 | 103 (30) | 1.37 | (0.78,2.42) | 0.278 | |
| 3C | 89 (46) | 3.28 | (1.98,5.41) | <0.001 | 66 (34) | 3.29 | (1.87,5.77) | <0.001 | |
| ECOG Category | 0 | 267 (73) | 1.0 (Ref) | - | - | ||||
| ≥1 | 34 (14) | 1.88 | (1.06,3.34) | 0.032 | |||||
| Breslow Depth | per mm | 266 (85) | 1.14 | (1.07,1.21) | <0.001 | 266 (85) | 1.1 | (1.02,1.18) | 0.012 |
| Recurrence prior to adjuvant therapy | No | 252 (81) | 1.0 (Ref) | - | - | ||||
| Yes | 65 (19) | 0.85 | (0.51,1.40) | 0.520 | |||||
| Radiation | No | 264 (80) | 1.0 (Ref) | - | - | ||||
| Yes | 53 (20) | 1.60 | (0.98,2.62) | 0.060 | |||||