(A) RNA was isolated from IM-FEN cultured at 33°C or 39°C (3 days) and amplified for cRet, Kcnn4, NaV_1.3, TASK1, Clca1, and GAPDH (loading control), n=3. The two lanes/gene correspond to RNA isolated from cells grown at 33°C and 39°C. (B) Histogram for IM-FEN mRNA assessed by Real Time PCR showing the relative level of expression of various channels and neuronal markers, Peripherin and Ret after normalization to GAPDH expression. Results are mean ± S.E., n=3. **P < 0.01, ***P < 0.001.