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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Dig Dis Sci. 2013 Jan 31;58(6):1516–1527. doi: 10.1007/s10620-013-2557-5

Figure 6. A hypoosmotically activated chloride current.

Figure 6

A) Whole cell voltage clamp recording at Vh= −60mV initiated an inward current upon the perfusion of hypoosmotic solution (230mOsm). This current was inhibited and remained inhibited after treatment with 10μM DCPIB. B) IV- relationship showing swelling activated current and inhibition by DCPIB. C) Whole cell recording of IM-PEN with Vh = +30mV. Addition of hypoosmotic solution initiated an outward current which was inhibited when Cl− was replaced in the external solution with gluconate. The current returned when Cl− was returned to the external solution.