Table 1.
EC50 for Phe contraction, ACh relaxation, and ER agonist-induced relaxation in cephalic, thoracic and abdominal arteries of female rat
| Parameter | Thoracic Aorta | Carotid | Pulmonary | Abdominal Aorta | Mesenteric | Renal |
|---|---|---|---|---|---|---|
|
| ||||||
|
pEC50 (−log M) Phe Contraction |
||||||
| + Endo | 7.74±0.06 | 7.81±0.06 | 8.03±0.04*T,C | 7.43±0.05*T,C,P | 6.59±0.08*T,C,P,A | 6.99±0.07*T,C,P,A,M |
| − Endo | 8.14±0.08# | 7.93±0.09 | 8.11±0.12 | 7.74±0.06# | 6.33±0.14 | 7.07±0.14 |
|
| ||||||
|
pEC50 (−log M) Relaxation of Phe Contraction ACh |
6.33±0.05 | 5.56±0.37 | 6.29±0.07 | 6.12±0.19 | 5.75±0.46 | 6.31±0.15 |
| E2 | 6.72±1.10 | 2.55±0.38 *T | 3.44±0.97 *T | 5.39±0.59*C | 4.08±0.56 *T,C | 5.71±0.40*c,p,m |
| −Endo | 2.03±0.20# | 3.28±0.56 | 3.15±0.51 | 3.85±0.65 *T | 4.91±0.69*t | 4.51±0.45*t |
| PPT | 6.86±0.89 | 3.65±0.62 *T | 4.29±0.78 *T | 6.06±0.60*C | 5.46±1.08 | 5.96±0.28*C |
| −Endo | 3.23±0.51# | 3.37±0.50 | 2.28±0.28# | 4.96±0.92*P | 5.66±0.88 *T,C,P | 5.69±0.65 *T,C,P |
| DPN | 7.64±1.33 | 6.52±1.54 | 3.45±0.85 *T | 6.33±0.35*P | 5.77±0.85 | 5.95±0.85 |
| −Endo | 1.76±0.00# | 4.19±1.54 | 4.73±2.97 | 7.14±1.34 *T | 5.68±0.72 *T,C | 7.01±0.89*t |
| G1 | 7.71±1.89 | 7.15±1.30 | 4.75±1.55 | 4.64±0.99 | 8.26±1.16 | 5.35±0.82 |
| −Endo | 1.76±0.00# | 3.53±1.03 | 2.63±0.73 | 7.56±1.13 *T,C,P | 7.30±0.40 *T,C,P | 6.23±0.34 *T,P |
|
| ||||||
|
pEC50 (−log M) Relaxation of KCl Contraction |
||||||
| E2 | 2.54±0.40 | 3.57±0.52 | 3.18±0.49 | 3.52±0.78 | 4.11±0.84 | 4.07±0.56 |
| PPT | 3.09±0.66 | 4.96±0.66 | 2.50±0.50*C | 5.36±0.84 *T,P | 8.90±0.62 *T,C,P,A | 6.68±1.07 *T,P |
| DPN | 1.76±0.00 | 4.01±0.73 *T | 1.76±0.00*C | 5.67±1.16 *T,P | 5.97±0.98 *T,P | 5.09±0.90*t,p |
| G1 | 3.50±1.74 | 3.91±0.89 | 1.76±0.00 | 6.56±1.22*P | 8.64±0.75*C,P | 6.27±1.15*P |
Data represent means±SEM, n= 8 to 10.
*
Significantly different (p<0.05) from corresponding measurement in thoracic aorta [T], carotid [C], pulmonary [P], abdominal aorta [A], mesenteric [M] and renal artery [R].
#
Measurements in endothelium-denuded vessels (−Endo) are significantly different (p<0.05) from corresponding measurements in intact vessels.