. Author manuscript; available in PMC: 2013 May 27.

Published in final edited form as: Exp Gerontol. 2011 Mar 29;46(8):643–659. doi: 10.1016/j.exger.2011.03.003

Table 3. Genes found to be upregulated in purified CD11b+ cells by RNA sequencing.

Cd11b+ cells were isolated from the PFC of Adult and Old-aged mice as described in Methods and RNA was subjected to next-generation RNA sequencing. Aging was found to be associated with upregulation of numerous CD antigens, chemokine related genes, complement genes, genes in the Jak-Stat and/or intereferon signaling pathway, cellular adhesion genes, MHC related genes, and Toll-like receptors in microglial cells.

CD antigens	Integrins	Other immune related genes
Cd3eap	Bcam	Atp1b3
Cd52	Itga3	Bst2
Cd59a	Itgax (“Cd11c”)	Csf2ra
Cd63	Itgb4	Ctsd
Cd74	Ncam1	Ddr1
Cd81	MHC related	F3
Cd9	B2m	Fgfr1
Chemokines	H2-ab1	Fgfr2
Cxcl10	H2-d1	Fgfr3
Cxcl13	H2-k1	Flt3
Cxxc1	Lag3	Fth1
Complement factors	Jak-Stat pathway	Igsf8
C1qa	Cntfr	Il4ra
C1qb	Il11ra1	Lamp1
C3	Irf2bp1	Lpl
C4b	Irf3	Ltbr
	Osmr	Mcam
	Prlr	Plxnb2
	Ptpn11	Rps6kb2
	Stat2	Serping1
	Stat3	Sirpa
	Toll-like receptors	Slc44a1
	Tlr2	Trf

Inline graphic IRG

Inline graphic Non-IRG