Table 2. Typical parameters and precisiona of estimates for Model data set patients (n=418 patients).
| Parameter | Population value | Median of individual predictions | Interindividual variability | Residual variability |
|---|---|---|---|---|
| hCG0 (IU l−1)b |
14 400 (5.7%) |
16 574 |
152% |
34.4% (1.4%) |
| K (per day) |
0.169 (1.3%) |
0.174 |
306% (6.7%) |
ND |
| hCGres (IU l−1) | 24.7 (11%) | 21.97 | 35% (4.9%) | ND |
Abbreviations: hCG=human chorionic gonadotrophin; hCGres=hCG resistant; ND=not determined.
a
Precision of parameter estimates were computed from a 100 resampling bootstrap analysis.
b
hCG0 individual parameters were assumed to follow a Box–Cox (BOCOX) distribution and were implemented as follows: BCOX1=((EXP(ETA(1)))**SHAPE1—1)/SHAPE1; hCG0=THETA(1)*EXP(BCOX1) with SHAPE1 estimated at −0.207 (s.e.: 7.6%), and ETA(1) a random variable following a normal distribution of mean 0 and variance estimated at 4.24 (s.e.: 3.5%).