Figure 5.

Incorporation of a disease activity index into dose calculations allows an accurate prediction of circulating insulin-like growth factor-1 (IGF-1). Utility function results showing the effect of increasing sophistication on dose scaling method. Scaling by weight, age group and Pediatric Crohn's Disease Activity Index score limits average IGF-1 concentrations in 93% of children to less than +2 SD score (SDS). Solid lines are the target range of 0 to +2 SDS, dashed lines are for reference −2 SDS and +2.5 SDS.