Table 2.
Parameter estimates from the model including non-parametric 95% CI from a bootstrap of 714 successful runs
| Parameter | Estimate | Bootstrap median | Bootstrap 2.5th percentile | Bootstrap 97.5th percentile |
|---|---|---|---|---|
| CL (l/h/70 kg) | 1.61 | 1.60 | 1.36 | 1.82 |
| VD (l/70 kg) | 2.42 | 2.41 | 1.78 | 3.10 |
| KSYN (µg/h) | 433 | 423 | 352 | 490 |
| Ka (h−1) | 0.10 | 0.10 | 0.083 | 0.12 |
| Coefficient of PCDAI on KSYN | −6.57 | −6.41 | −8.19 | −4.89 |
| IIV on CL (%CV) | 10.38 | 9.46 | 3.49 | 15.1 |
| IIV on KSYN (%CV) | 24.61 | 24.10 | 9.98 | 33.58 |
| Residual error proportional (%CV) | 9.81 | 9.69 | 7.85 | 11.04 |
| Residual error, additive (µg/l) | 28.32 | 25.93 | 13.29 | 42.78 |
IIV, interindividual variability; PCDAI, Pediatric Crohn's Disease Activity Index.