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. Author manuscript; available in PMC: 2013 May 30.
Published in final edited form as: J Mol Neurosci. 2012 Jan 18;48(2):368–386. doi: 10.1007/s12031-012-9707-7

Figure 7. Schematic drawings of cell signaling pathways leading to CACNA1H gene expression and Cav3.2 channels incorporation during stressor stimulation.

Figure 7

The final result of β1-adrenergic receptor stimulation and chronic/intermittent hypoxia is the activation of transcription factors (HIF, CREB, …) and CACNA1H gene expression that lead to Cav3.2 channel incorporation into the plasma membrane. The pathway driven by β1-adrenergic receptor stimulation (isoprenaline, forskolin, pCPT-cAMP) is derived from Novara et al. (2004). The pathway induced by chronic/intermittent hypoxia (NOX, ROS, PLC, PKG, HIF) is taken from Yuan et al. (2008).