Table 3.

Urinary cortisol excretion outside the normal range* and change from baseline relative to the normal range (intent-to-treat population)

	Relative to normal range*	FF/VI 100/25 µg OD (N=201)	FF/VI 200/25 µg OD (N=202)	FP 500 µg BD (N=100)
Baseline	n	166	169	94
n (%)	High	12 (7)	14 (8)	7 (7)
	Normal	150 (90)	146 (86)	85 (90)
	Low	4 (2)	9 (5)	2 (2)
Any visit post-baseline	n	183	179	87
n (%)	High	32 (17)	31 (17)	11 (13)
	Normal	132 (72)	138 (77)	57 (66)
	Low	19 (10)	10 (6)	19 (22)
Change from baseline	n	156	156	83
(any visit post-baseline)	To high	25 (16)	21 (13)	8 (10)
n (%)	To normal or NC	119 (76)	126 (81)	58 (70)
	To low	12 (8)	9 (6)	17 (20)

*Normal range is 11–138 nmol/24 h.

BD, twice daily; FF, fluticasone furoate; FP, fluticasone propionate; NC, no change; OD, once daily; VI, vilanterol.