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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: J Inherit Metab Dis. 2012 Oct 30;36(3):479–490. doi: 10.1007/s10545-012-9551-5

Fig. 4.

Fig. 4

Transport-related mRNA in choroid plexus. Expression of transport related genes, MRP1/Abcc1 and Glutathione-S-transferase (Gst), in choroid plexus were analyzed in LPS, HI50, HI20, and LPS/HI groups. MRP1 mRNA expression was not altered by either LPS (a) or HI50 (c) but was significantly upregulated in the left plexus after LPS/HI (e). Immunoreactivity for MRP1 in control PND9 choroid plexus was specifically localized to the basolateral membranes of the epithelial cells (g). The staining pattern was not affected by LPS, HI20/50 or LPS/HI, and no staining was detected in other parts of brain (not illustrated). Gst mRNA expression was not significantly affected by LPS (b) while it was strongly increased at 2- and 24-h in HI50 (d) and LPS/HI groups (f). RT-PCR data in LPS group are shown as fold change over control±SEM. RT-PCR data in HI50, HI20, and LPS/HI groups are shown as fold change between left and right ventricular (left/right) plexus±SEM, *p≤0.05, **p≤0.01. Scale bar in D represents 25 μm