Table 1.

Mitochondrial Variants Detected in Breast Cancer Tissues (nc= Noncoding; nr= Not reported; syn= Synonymous; *= Significant P-value).

Gene	Nucleotide Position	Nucleotide Change	Amino Acid Change	P-value	Reference
16S rRNA	3197	T>C	Nc	0.03*	Bai et al., 2007
ND1	3918	G>A	Syn	nr	Parrella et al., 2001
	4216	T>C	Y-->H	0.598	Covarrubias et al., 2008
ATP6	9055	G>A	A-->T	0.005*	Bai et al., 2007
ND3	10397	A>G	syn	0.030*	Fang et al., 2010
	10398	A>G	T -->A	0.011*	Covarrubias et al., 2008
	10400	C>T	syn	0.040*	Fang et al., 2010
ND4	11719	G>A	syn	0.005*	Tommasi et al., personal data
	11900	G>A	V-->M	nr	Parrella et al., 2001
TL2	12308	A>G	nc	0.84	Covarrubias et al., 2008
ND5	12344	T>A	M-->K	nr	Parrella et al., 2001
	13708	G>A	A-->T	0.0006*	Bai et al., 2007
CYTB	14869	G>A	syn	nr	Parrella et al., 2001
D-Loop	16093	C>T	nc	nr	Parrella et al., 2001
	16183	A>C	nc	0.03*	Tommasi et al., personal data
	16278	C>T	nc	0.03*	Tommasi et al., personal data
	16290	C>T	nc	0.002*	Sultana et al., 2012
	16292	C>T	nc	0.663	Ma et al., 2011
	16293	del-A	nc	0.010*	Sultana et al., 2012
	16304	T>C	nc	0.252	Czarnecka et al., 2010a
	16390	G>A	nc	1.00	Czarnecka et al., 2010a
	16519	T>C	nc	0.036*	Bai et al., 2007
	153	A>G	nc	0.009*	Tommasi et al., personal data
	195	T>C	nc	0.04*	Tommasi et al., personal data
	225	G>A	nc	0.03*	Tommasi et al., personal data
	226	T>C	nc	0.03*	Tommasi et al., personal data
	D310	insC	nc	<0.0001*	Xu et al., 2012