Fig. (2).

The structure of PAH. (A) The modeled structure of full-length tetrameric PAH (composite model prepared by combining the structures of tetrameric human PAH (residues 118-452; PDB 2PAH) and dimeric rat PAH (residues 19-427; PDB 2PHM)). (B) Detailed structure of PAH including thienylalanine and BH4 (PDB 1KW0).