Fig. (1).

Main endocytic and autophagic pathways. Upper part depicts from left to right: i) fluid phase endocytic uptake of extracellular fluid containing small molecules; ii) receptor-mediated endocytic uptake of specific ligands, generally within clathrin-coated vesicles; and iii) phagocytic uptake of solid particles such as bacteria. Lower part represents from left to right: i) macroautophagy of cytosolic components including organelles; ii) chaperone mediated autophagy of proteins harboring KFERQ-related sequences; iii) microautophagy of cytosolic material. See text for further details.