. Author manuscript; available in PMC: 2013 May 27.

Published in final edited form as: Kidney Int. 2012 Apr 18;82(2):220–225. doi: 10.1038/ki.2012.107

Table 2. Meta-analyses findings for type 2 diabetes-SNP associations for eGFR and log UACR residuals.

Trait	SNP	Loci/gene	Coded Allele	Other Allele	β	SE	P-value	Number	P-value for heterogeneity	Direction of effect for coded allele
eGFR	rs8050136^*	FTO	A	C	-0.078	0.0253	0.002	6835	0.13	↑BMI and T2D
	rs9939609^*	FTO	A	T	-0.0751	0.0252	0.003	6802	0.18	↑BMI and T2D
	rs5219	KCNJ11	T	C	-0.0543	0.0178	0.002	6807	0.91	↑T2D
	rs7901695^*	TCF7L2	C	T	-0.0884	0.0265	0.0008	6834	0.24	↑T2D
	rs7903146^*	TCF7L2	T	C	-0.0758	0.0269	0.005	6837	0.17	↑T2D
	rs10010131^†	WFS1	G	A	0.0704	0.0252	0.005	6837	0.07	↑T2D
UACR
	rs10010131	WFS1	G	A	0.0684	0.0263	0.009	6784	0.34	↑T2D

SNP, single nucelotide polymorphism; SE, standard deviation; eGFR, estimated glomerular filtration rate; log UACR (urine albumin-to-creatinine ratio); T2D, type 2 diabetes

FTO variants (rs8050136 and rs9939609) and TCF7L2 variants (rs7901695 and rs7903146) are in linkage disequilibrium: r²>0.95 in the overall sample and within each center.

^†

Estimates for the family study are: beta (se) = 0.12 (0.04), p=0.0008) and for cohort study beta (se) = -0.02 (0.04), p=0.63.