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. Author manuscript; available in PMC: 2013 May 27.
Published in final edited form as: Diabetes Metab Res Rev. 2011 Nov;27(8):883–886. doi: 10.1002/dmrr.1266

Figure 1. Location of amino acids that potentially contribute to an “un-restricted” epitope in ZnT8.

Figure 1

A. Alignment between the C terminal domains of mouse and human ZnT8. Variant residues are shown in red with the polymorphic residue 325 highlighted. B. Residues 268–357 of human ZnT8(R325) were modeled based on the X-ray crystal structure of E. coli Yiip (PDB:2QFI). Residues that vary between human and mouse are shown in red (contributing) or blue (non-contributing). Two conserved serines that might also contribute to the epitope are shown in orange