Table 2. Ontology analysis of genes differentially expressed between EBV blasts and CD40L/IL-4 blasts.

Gene-sets	Ontological term	Hit count	Fold Enrichment	P Value
A. EBV≠CD40L/IL-4	Interferon-mediated immunity	11	11.6	<0.0001
	Cytokine/chemokine mediated immunity	9	5.2	0.0004
	B-cell- and antibody-mediated immunity	7	5.1	0.0025
	Macrophage-mediated immunity	10	4.9	0.0002
	Cytokine and chemokine signaling pathway	14	3.9	<0.0001
	T-cell mediated immunity	10	3.7	0.0016
	Immunity and defense	53	2.8	<0.0001
	Ligand-mediated signaling	14	2.4	0.0063
B. EBV>CD40L/IL-4	Interferon-mediated immunity	11	23.3	<0.0001
	Macrophage-mediated immunity	7	7.0	0.0005
	Immunity and defense	28	3.0	<0.0001
C. EBV<CD40L/IL-4	T-cell mediated immunity	9	6.5	<0.0001
	Cytokine and chemokine signaling pathway	8	4.4	0.0021
	Immunity and defense	25	2.6	<0.0001
	Cell communication	18	2.1	0.0052
	Signal transduction	39	1.6	0.0021

Ontology analysis of genes differentially expressed between EBV and CD40L/IL-4 blasts by paired LIMMA (p<0.01, FC>2) was performed using the DAVID v6.7 bioinformatics resource [28], [29] to identify Panther Biological Processes terms for which there was a significant enrichment of genes. The lists of probe-sets entered into DAVID v6.7 and the complete analyses readouts are given in Data-File S1. The probe-sets analyzed were those which were: (A) differentially expressed between EBV and CD40L/IL-4 blasts at day 7, (B) the subset of differentially expressed genes that was expressed higher in EBV blasts than in CD40L/IL-4 blasts, and (C) the subset of differentially expressed genes that was expressed lower in EBV blasts than in CD40L/IL-4 blasts.