Table 4. Expression of IL4-regulated genes by EBV-infected B blasts.
| Comparisons between gene sets* | overlap between gene-sets | Odds Ratio | Chi-Square | P Value (1 df) | ||
| A. | Up-regulated by IL4 (n = 567) and: | ISGs (n = 370) | 30 | 2.5 | 23.2 | <0.0001 |
| IRF-1 up-regulated genes (n = 113) | 3 | 0.76 | 0.209 | 0.648 | ||
| Up-regulated by EBV (n = 370) | 12 | 0.94 | 0.047 | 0.828 | ||
| Up- regulated by CD40L/IL4 (n = 370) | 42 | 3.8 | 66.8 | <0.0001 | ||
| Down-regulated by EBV (n = 370) | 35 | 3.0 | 38.7 | <0.0001 | ||
| Down- regulated by CD40L/IL4 (n = 263) | 17 | 2.0 | 6.90 | 0.009 | ||
| Differentially expressed between EBV and CD40L/IL4 blasts (n = 249) | 34 | 4.6 | 75 | <0.0001 | ||
| Higher in EBV blasts than CD40L/IL4 blasts (n = 134) | 7 | 1.5 | 1.22 | 0.269 | ||
| Lower in EBV blasts than CD40L/IL4 blasts (n = 115) | 27 | 8.9 | 134 | <0.0001 | ||
| B. | Down-regulated by IL4 (n = 452) and: | ISGs (n = 370) | 111 | 19.6 | 998 | <0.0001 |
| IRF-1 up-regulated genes (n = 113) | 66 | 57.7 | 1271 | <0.0001 | ||
| Up-regulated by EBV (n = 370) | 60 | 7.7 | 244 | <0.0001 | ||
| Up- regulated by CD40L/IL4 (n = 370) | 27 | 2.9 | 27.8 | <0.0001 | ||
| Down-regulated by EBV (n = 370) | 26 | 2.8 | 24.6 | <0.0001 | ||
| Down- regulated by CD40L/IL4 (n = 263) | 29 | 4.6 | 65.4 | <0.0001 | ||
| Differentially expressed between EBV and CD40L/IL4 blasts (n = 249) | 49 | 9.6 | 259 | <0.0001 | ||
| Higher in EBV blasts than CD40L/IL4 blasts (n = 134) | 44 | 19.0 | 441 | <0.0001 | ||
| Lower in EBV blasts than CD40L/IL4 blasts (n = 115) | 5 | 1.6 | 1.06 | 0.303 | ||
*
Numbers in parentheses indicate the number of genes within the gene-set analyzed. Comparisons were restricted to the 16420 genes present on both the HuExon 1.0 ST and the U133 plus2 Affymetrix array platforms. The IL-4 regulated genes were identified experimentally by Elo et al who arrayed IL-2 stimulated T cells treated with or without IL-4 [35]. Complete gene-lists are available in Data-File S2.